$50 Billion and Counting — The U.S. Manufacturing Buildout

Since 2020 Lilly has committed more than $50 billion to U.S. manufacturing — the largest such investment by any pharmaceutical company in U.S. history. Lebanon, Indiana is now a $9 billion site for tirzepatide API. The Lilly Medicine Foundry adds $4.5 billion for advanced manufacturing and clinical-trial production. In February 2025 Lilly announced four additional new sites. This module walks you through the manufacturing footprint, why it matters, and how to talk about it whether you're interviewing for an operations, engineering, quality, supply chain, or commercial role.